The lab seeks to understand the brain circuitry underlying motivated behaviors. Our current work focuses on four main areas and their overlap: neurocircuitry of the extended amygdala, neuropeptide molecules, the role of stress in addiction, and sleep/wake biology.
Extended Amygdala Circuitry
The BNST (bed nucleus of the stria terminalis) is a part of the extended amygdala in the ventral forebrain. It is an intriguing brain region due to its high level of molecular diversity and complex pattern of output projections. We are interested in exploring the roles that these diverse neurons play in both hedonic states (stress, reward) and homeostatic states (sleep, feeding).
Neuropeptides
Neuropeptides are neuroactive molecules that have unique signaling properties, and their discrete expression patterns permit a greater level of specificity when classifying neuronal subtypes. Our previous work identified subsets of neurons in the extended amygdala that express distinct neuropeptides and drive opposing emotional states. We aim to continue this line of work by investigating functional and behavioral significance of neuropeptide release across multiple brain pathways that control emotional behaviors.
Addiction & Stress
Using behavioral paradigms paired with simultaneous physiological monitoring or manipulation of neuronal activity, we are investigating how stress and reward responses are altered by alcohol addiction. By identifying the specific neural circuits underlying behavioral changes in addiction, we can identify potential targets for future therapeutics.
Sleep/Wake Mechanisms
The neural pathways controlling sleep and wakefulness (arousal) are essential for healthy cognitive and emotional health. The precise mechanisms governing how sleep and arousal circuits respond to stressful and rewarding experiences remain largely unknown. Our lab is interested in elucidating the role that specific BNST neuropeptides play in regulating those mechanisms, particularly in psychiatric states of anxiety and substance abuse.